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(A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; <t>C21,</t> <t>compound</t> <t>21</t> (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.
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(A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; <t>C21,</t> <t>compound</t> <t>21</t> (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.
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(A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; C21, compound 21 (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.

Journal: Cell reports

Article Title: Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia

doi: 10.1016/j.celrep.2025.116803

Figure Lengend Snippet: (A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; C21, compound 21 (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.

Article Snippet: Compound 21 dihydrochloride (C21) , Hello Bio , HB6124.

Techniques: Injection, Saline